To be unable to attend an event, meeting, or appointment; to be unable to be present at a specified time or place.
2.
Globalneutral
To be unable to achieve or accomplish something; to fail to succeed in doing what is required or intended.
3.
Globalinformal
To be unable to understand or resolve something (in contexts such as 'cannot make it out' or 'cannot make it of'), though this is an extended use dependent on additional phrasing.